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Correlates of prepubertal bone mineral density in cystic fibrosis

R H Haslam1, D J Borovnicar, D B Stroud

  • 1Department of Paediatrics, Royal Children's Hospital, Melbourne, Australia. rikhas@hotmail.com

Archives of Disease in Childhood
|July 24, 2001
PubMed

Insights

Early bone mineral density in children with cystic fibrosis (CF) is not significantly affected by disease severity or lifestyle factors. Focus on nutrition and general health is recommended to support bone growth in CF patients.

Area of Science:

  • Pediatric Endocrinology
  • Pulmonology
  • Bone Metabolism

Background:

  • Osteopenia is a common complication in cystic fibrosis (CF).
  • Understanding early bone mineral accretion factors is crucial for long-term bone health in children with CF.

Purpose of the Study:

  • To investigate early determinants of bone mineral density (BMD) in prepubertal children with CF.
  • To explore the relationship between BMD and various health and lifestyle indicators in this population.

Main Methods:

  • Studied 22 prepubertal children diagnosed with CF and mild lung disease.
  • Assessed total body bone mineral density (BMD) against body composition, biochemical markers, lung function, and physical activity levels.

Main Results:

  • A mild, non-significant reduction in mean total body BMD was observed.
  • No significant correlations were found between BMD and anthropometrics, fat-free mass, lung disease severity, fat malabsorption, energy intake, or physical activity.
  • Impaired physical growth was evident and correlated with lung disease severity.

Conclusions:

  • A specific factor related to cystic fibrosis (CF) is unlikely to be the primary cause of osteopenia.
  • Optimizing bone mineral accretion in children with CF necessitates attention to general lifestyle and nutritional factors.
Abstract

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