Related Experiment Video
Updated: Aug 1, 2026

Organelle Transport in Cultured Drosophila Cells: S2 Cell Line and Primary Neurons.
Published on: November 20, 2013
Cytoplasmic dynein subunit heterogeneity: implications for axonal transport
1Department of Cell Biology, School of Medicine, PO Box 800732, University of Virginia, Charlottesville, VA 22908, USA.
Abstract:
The formation and maintenance of neuronal synapses is dependent on the active transport of material between the cell body and the axon terminal. Cytoplasmic dynein is one motor for microtubule-based axonal transport. Two pools of cytoplasmic dynein have been identified in the axon. They are distinguished by their intermediate and light intermediate chain subunits. Each pool is transported at different rates down the axon in association with different proteins or organelles. This review presents several models to discuss the potential functional roles of these different pools of cytoplasmic dynein during axonal transport.
Related Concept Videos
Polarity of the Cytoskeleton
Microtubule Associated Motor Proteins
The Movement of Organelles and Vesicles
Assembly of Complex Microtubule Structures
Microtubules in Cell Motility
Anaphase A and B
Plus-end depolymerization releases tubulin heterodimers from the terminal region of the microtubule. As tubulin subunits are lost, the Ndc80 complexes detach...

