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The implication of repeated versus continuous strain on nerve function in a rat forelimb model.

M Watanabe¹, M Yamaga, T Kato

¹Department of Orthopaedic Surgery, School of Medicine, Kumamoto University, Kumamoto, Japan.

The Journal of Hand Surgery

|July 24, 2001

Summary

Repeated nerve strain, even at low levels, can cause nerve dysfunction. This study found that continuous strain had no effect, but repeated strain led to nerve damage and functional deficits.

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Area of Science:

Neuroscience
Biomedical Engineering
Orthopedics

Background:

Nerve strain is a potential cause of upper extremity symptoms.
The effects of repeated versus continuous nerve strain are not well understood.

Purpose of the Study:

To investigate the differential effects of continuous and repeated nerve strain on nerve function.
To determine if low-level nerve strain, applied repeatedly, can lead to nerve dysfunction.

Main Methods:

A rat forelimb model was used to apply continuous and repeated strain to the medial cord of the brachial plexus.
Nerve histology (blood-nerve barrier integrity), function (grasping strength), and electrophysiology were assessed.

Main Results:

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Continuous nerve strain at 2 N for 1 hour did not result in any observable histologic, functional, or electrophysiologic changes.

Repeated nerve strain at 120 times per hour caused significant abnormalities in nerve histology, grasping strength, and nerve conduction.

Conclusions:

Repeated nerve strain, unlike continuous strain, can induce nerve dysfunction and damage.
These findings may elucidate the etiology of nonspecific neural symptoms in patients with inconclusive objective findings.