Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Motor unit number estimation, ALS and clinical trials.

C L Gooch1, Y Harati

  • 1Department of Neurology, Columbia College of Physicians and Surgeons, New York, USA.

Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders : Official Publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
|July 27, 2001
PubMed
Summary

Motor unit number estimation (MUNE) techniques are crucial for tracking motor neuron disease progression. These methods help evaluate new treatments for amyotrophic lateral sclerosis (ALS) by quantifying motor unit physiology.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Diabetic peripheral neuropathies.

Methodist DeBakey cardiovascular journal·2010
Same author

What's in the Literature?

Journal of clinical neuromuscular disease·2009
Same author

Neuromuscular highlights from the american academy of neurology annual meeting.

Journal of clinical neuromuscular disease·2008
Same author

Quantitative objective markers for upper and lower motor neuron dysfunction in ALS.

Neurology·2007
Same author

Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial.

Neurology·2006
Same author

Glutamine as a neuroprotective agent in high-dose paclitaxel-induced peripheral neuropathy: a clinical and electrophysiologic study.

Clinical oncology (Royal College of Radiologists (Great Britain))·2005

Area of Science:

  • Neurology
  • Neurophysiology

Background:

  • Motor unit number estimation (MUNE) has advanced significantly.
  • MUNE is increasingly used in amyotrophic lateral sclerosis (ALS) research.
  • Quantitative physiological measures are vital for clinical trials in motor neuron diseases.

Purpose of the Study:

  • To review modern MUNE techniques.
  • To assess the reproducibility and utility of MUNE in ALS patients.
  • To highlight MUNE's role in evaluating therapeutic interventions for ALS.

Main Methods:

  • Review of current MUNE methodologies.
  • Analysis of existing data on MUNE in ALS.
  • Focus on MUNE's application in clinical trials.

Main Results:

Related Experiment Videos

  • MUNE techniques have evolved substantially.
  • Data support the reproducibility and utility of MUNE in ALS.
  • MUNE is valuable for assessing treatment efficacy.

Conclusions:

  • Modern MUNE techniques offer quantitative insights into motor unit physiology.
  • MUNE is a valuable tool for ALS research and clinical trials.
  • Further application of MUNE is essential for developing effective ALS therapies.