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Cardiac cellular actions of hydrochlorothiazide.

L Galán1, T Ferrer, A Artiles

  • 1Laboratorio de Electrofisiología, Instituto de Cardiología y Cirugía Cardiovascular, La Habana, Cuba Laboratorio de Fisiología Cardiovascular, Instituto de Fisiología, Universidad Autónoma de Puebla, Puebla, Mexico.

Fundamental & Clinical Pharmacology
|July 27, 2001
PubMed
Summary

Hydrochlorothiazide (HCTZ) depresses heart muscle contraction by blocking key sodium and calcium channels. This negative inotropic action, observed at high concentrations, may explain its limited impact on cardiac action potential duration.

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