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Related Experiment Videos

Ischemic colitis associated with paclitaxel.

B Daniele1, G B Rossi, S Losito

  • 1Department of Medical Oncology, National Cancer Institute and G. Pascale Foundation, Naples, Italy. bdaniele@sirio-oncology.it

Journal of Clinical Gastroenterology
|July 27, 2001
PubMed
Summary
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Chemotherapy with carboplatin and paclitaxel can cause ischemic colitis in cancer patients, presenting as abdominal pain and bloody diarrhea. This diagnosis should be considered when Clostridium difficile infection is ruled out, especially with a normal white blood cell count.

Area of Science:

  • Oncology
  • Gastroenterology
  • Pathology

Background:

  • Colonic toxicity is a known complication of systemic chemotherapy in cancer patients.
  • Pseudomembranous colitis and ischemic colitis are potential gastrointestinal toxicities.
  • Paclitaxel, a common chemotherapy agent, is associated with gastrointestinal mucosal necrosis and angiogenesis inhibition.

Observation:

  • A 49-year-old woman with metastatic neuroendocrine tumor developed mild ischemic colitis after carboplatin and paclitaxel chemotherapy.
  • She presented with abdominal pain and bloody diarrhea, indicative of gastrointestinal toxicity.
  • Diagnostic workup excluded Clostridium difficile infection, and sigmoidoscopy revealed mild, transient ischemic colitis.

Findings:

  • Chemotherapy-induced ischemic colitis can occur in cancer patients, even with mild presentations.

Related Experiment Videos

  • Paclitaxel's known effects on gastrointestinal mucosa and angiogenesis may contribute to ischemic colitis development.
  • A normal white blood cell count in a patient with gastrointestinal toxicity and cancer warrants consideration of ischemic colitis.

    • Implications:

    • This case highlights the importance of considering ischemic colitis in cancer patients experiencing gastrointestinal toxicity during chemotherapy, particularly when C. difficile is excluded.
    • Clinicians should be aware of paclitaxel's potential to induce ischemic colitis.
    • Early diagnosis and management of chemotherapy-induced ischemic colitis can improve patient outcomes.