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[Controlled-release drugs: administration routes and formulations]
1Dipartimento Farmaceutico, Parcó Area delle Scienze 27/A, Università di Parma, Parma, Italia.
Annales Pharmaceutiques Francaises
|July 27, 2001
Summary
Controlled drug delivery systems, evolving since the 1970s, optimize medication release rates and sites. This review explores current oral, transdermal, and respiratory systems, their pros, cons, and future research directions.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Technology
Context:
- The concept of controlled release formulations has evolved significantly since the 1930s.
- The 1970s marked a pivotal period with the introduction of "therapeutic systems" and novel pharmaceutical formulations.
- Modern drug delivery research extends beyond release rate to encompass targeted release site optimization.
Purpose:
- To define controlled drug delivery.
- To elucidate the fundamental principles and advantages/disadvantages of existing controlled release systems.
- To examine current research trends in drug delivery.
Summary:
- This review covers the historical development of controlled release technology.
- It details definitions, fundamental principles, and comparative analysis of marketed oral, transdermal, and respiratory delivery systems.
- Examples of current research in advanced drug delivery are also presented.
Impact:
- Provides a comprehensive overview of controlled release drug delivery systems.
- Facilitates understanding of the evolution and current state of pharmaceutical formulations for optimized drug therapy.
- Highlights future research avenues in targeted and controlled drug release mechanisms.