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Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?
M A Burrull-Madero1, A Del-Villar-Ruiz, S Grau-Cerrato
1Servicio de Farmacia, Hospital Universitario del Mar, Paseo Marítimo 25-29, 08003, Barcelona, Spain. 88544@imas.imim.es
Abstract:
An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum. Metformin is described as a glucose-lowering agent for treatment of type 2 diabetes mellitus and as antiobesity drug, though results achieved with this last indication are not conclusive. But metformin has fibrinolytic features by means of diminished plasminogen activator inhibitor 1 activity. Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.
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