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Related Experiment Videos

A multi-modality assay platform for ultra-high throughput screening.

A Fowler1, I Davies, C Norey

  • 1Amersham Pharmacia Biotech UK Limited, Little Chalfont, Buckinghamshire, England. leadseeker@eu.apbiotech.com

Current Pharmaceutical Biotechnology
|July 27, 2001
PubMed
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High-density microplates and advanced imaging systems are revolutionizing drug discovery screening. The LEADseeker system enables ultra-high throughput screening across multiple assay types, accelerating hit identification.

Area of Science:

  • Drug discovery and development
  • Biotechnology
  • Assay development

Background:

  • Increasing demand for higher throughput and reduced reagent use in primary screening.
  • Limitations of traditional scintillation counters for radiometric assays with high-density microplates.
  • Need for versatile detection methods (fluorescence, luminescence, radioactivity) in drug discovery.

Purpose of the Study:

  • Introduce the LEADseeker Homogenous Imaging System as a solution for ultra-high throughput screening.
  • Highlight the system's multi-modality capabilities for various assay types.
  • Demonstrate the system's compatibility with high-density microplate formats.

Main Methods:

  • Utilizing Charged Coupled Device (CCD) camera-based imaging for whole-plate analysis in a single exposure.

Related Experiment Videos

  • Employing the LEADseeker system with integrated assay toolboxes for radiometric, fluorescent, and luminescent assays.
  • Adapting screening to 384- and 1536-well plate formats.

    • Main Results:

    • Significant acceleration of detection and analysis for high-density microplates.
    • Demonstrated compatibility with diverse biological assays including enzyme assays, receptor binding, and molecular interactions.
    • Enabled ultra-high throughput screening capabilities.

    Conclusions:

    • The LEADseeker system addresses the evolving needs of drug discovery by offering rapid, multi-modal imaging for high-density formats.
    • This technology facilitates ultra-high throughput screening, enhancing efficiency and scope in hit identification.
    • The platform supports a wide range of research areas, from enzyme kinetics to molecular interactions.