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Left ventricular diastolic function in systemic sclerosis.

G Aguglia1, A Sgreccia, M L Bernardo

  • 1Istituto di Clinica Medica I, Università La Sapienza, Rome, Italy.

The Journal of Rheumatology
|July 27, 2001
PubMed
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Systemic sclerosis (SSc) does not appear to cause primary diastolic dysfunction. Left ventricular diastolic dysfunction in SSc patients was only observed when other cardiac conditions were present.

Area of Science:

  • Cardiology
  • Rheumatology
  • Echocardiography

Background:

  • Systemic sclerosis (SSc) is an autoimmune disease that can affect multiple organs.
  • Left ventricular diastolic function is crucial for maintaining cardiac output.
  • The potential for primary diastolic dysfunction in SSc requires further investigation.

Purpose of the Study:

  • To evaluate left ventricular diastolic function in patients with SSc.
  • To determine if SSc itself causes primary diastolic dysfunction, independent of other cardiac conditions.

Main Methods:

  • 124 SSc patients and 41 healthy controls underwent comprehensive echocardiography.
  • Pulsed wave Doppler assessed key diastolic variables: peak early filling velocity (E), peak atrial filling velocity (A), E/A ratio, and early filling deceleration time.

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  • Patients were categorized into Group A (with potentially confounding cardiac conditions) and Group B (without).

    • Main Results:

    • Group A and the overall SSc population showed significant differences in diastolic function compared to controls.
    • Group B (SSc patients without other cardiac issues) exhibited no significant differences in diastolic function compared to controls.
    • Diastolic dysfunction was exclusively observed in SSc patients with co-existing conditions affecting diastolic function.

    Conclusions:

    • Left ventricular diastolic dysfunction in SSc is associated with other cardiac comorbidities, not SSc per se.
    • SSc does not appear to be an independent cause of primary diastolic abnormalities.
    • Further research should focus on managing comorbidities to preserve diastolic function in SSc patients.