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Microvessel density in pituitary adenomas and carcinomas
1Department of Anatomy, Campus Universitario de Lugo, Spain. svidal@lugo.usc.es
Virchows Archiv : an International Journal of Pathology
|July 27, 2001
Summary
Pituitary tumor vascularization, measured by microvessel density, varies by tumor type and age. Higher vascularity in carcinomas and macroadenomas in younger patients suggests age influences tumor growth potential.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Tumor growth necessitates angiogenesis, the formation of new blood vessels.
- Increased angiogenesis correlates with tumor growth and metastatic potential.
- Pituitary tumors require vascularization for growth and nutrient supply.
Purpose of the Study:
- To evaluate microvessel density in pituitary adenomas and carcinomas.
- To correlate microvessel density with tumor type, proliferation, invasiveness, and patient factors.
- To assess the impact of treatments on pituitary tumor vascularity.
Main Methods:
- Immunocytochemistry using CD-34 antigen to quantify microvessel density.
- Analysis of 157 pituitary adenomas and 7 pituitary carcinomas.
- Correlation with MIB-1 index, tumor invasiveness, gender, age, and treatment status.
Main Results:
- Lowest microvessel density in growth hormone-producing adenomas; highest in pituitary carcinomas.
- No significant correlation between MIB-1 index and microvessel density.
- Invasive tumors showed a trend towards higher vascularization.
- Age showed a positive correlation with microvessel density, particularly in macroadenomas.
- Significant differences in vascularity between microadenomas and macroadenomas in younger patients.
Conclusions:
- Microvessel density is a key factor in pituitary tumor behavior.
- Age is a significant factor influencing pituitary tumor vascularization.
- Further research into age-related neovascularization in pituitary tumors is warranted.