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Skin biopsy as a tool to assess distal small fiber innervation in diabetic neuropathy

M Polydefkis1, P Hauer, J W Griffin

  • 1Department of Neurology, The Johns Hopkins University, Baltimore, Maryland 21287, USA. mpolyde@jhmi.edu

Diabetes Technology & Therapeutics
|July 27, 2001
PubMed
Abstract

No abstract available in PubMed .

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Diabetic Neuropathy

DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...