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Related Experiment Videos

Localized amyloid deposition in trigger finger.

S Cordiner-Lawrie1, J Diaz, P Burge

  • 1Nuffield Orthopaedic Centre, Oxford, UK.

Journal of Hand Surgery (Edinburgh, Scotland)
|July 27, 2001
PubMed
Summary
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Localized amyloid deposition was found in the tendon sheath of over 20% of trigger finger patients over 46. These age-associated deposits may contribute to trigger finger development.

Area of Science:

  • Orthopedics
  • Pathology
  • Rheumatology

Background:

  • Trigger finger involves flexor tendon sheath (A1 pulley) degeneration and thickening, causing tendon constriction.
  • Idiopathic primary trigger finger is a common condition affecting hand function.

Purpose of the Study:

  • To investigate the presence and characteristics of amyloid deposition in idiopathic primary trigger finger.
  • To explore the potential link between amyloid and age-related changes in trigger finger.

Main Methods:

  • Histopathological examination of tendon sheath tissue from 47 idiopathic primary trigger finger cases.
  • Analysis of amyloid presence, location, and association with cellular and degenerative changes.

Main Results:

Related Experiment Videos

  • Amyloid deposition was identified in 11 cases (23%) of trigger finger.
  • Amyloid was exclusively found in patients over 46 years old.
  • Deposits were observed around cells and in areas of mucinous/fibrinoid degeneration containing glycosaminoglycans.

    • Conclusions:

    • Localized amyloid deposition occurs in a subset of middle-aged and elderly trigger finger patients.
    • The findings suggest amyloid deposition may be an age-associated phenomenon contributing to trigger finger pathology.
    • Further research is needed to clarify the pathogenic role of these amyloid deposits.