Related Experiment Video
Updated: Oct 5, 2026
VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
Published on: December 28, 2015
Molecular cloning and characterization of a novel SH3 protein (SLY) preferentially expressed in lymphoid cells
S Beer1, A B Simins, A Schuster
1Institute of Medical Microbiology, immunology and Hygiene, Technische Universität München, Munich, Germany. sbeer@lrz.tu-muenchen.de
Abstract:
A novel full-length cDNA was isolated from a murine T-cell lymphoma library that has an open reading frame encoding 381 amino acids. The predicted protein (termed SLY) contains a Src homology 3 domain and a sterile alpha motif, suggesting that it functions as a signaling adaptor protein in lymphocytes. Northern blot and in situ hybridization analysis showed a preferential expression in lymphoid tissues. The sly gene is located on the X-chromosome in close proximity to genes involved in various immune disorders. This is consistent with an additional role of SLY in immune pathology.
