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Mechanisms by which metals promote events connected to neurodegenerative diseases
A Campbell1, M A Smith, L M Sayre
1Department of Community and Environmental Medicine, University of California, Irvine, Irvine, CA 92697-1825, USA. aghadimi@uci.edu
Brain Research Bulletin
|July 27, 2001
Abstract:
Although the exact causative phenomenon responsible for the onset and progression of neurodegenerative disorders is at present unresolved, there are some clues as to the mechanisms underlying these chronic diseases. This review addresses mechanisms by which endogenous or environmental factors, through interaction with redox active metals, may initiate a common cascade of events terminating in neurodegeneration.