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Role played by the response regulator Ris in Bordetella bronchiseptica resistance to macrophage killing
K Zimna1, E Medina, H Jungnitz
1Division of Microbiology, GBF-German Research Centre for Biotechnology, Braumschweig, Germany.
FEMS Microbiology Letters
|July 27, 2001
Abstract:
Previous studies suggested that the persistence in eukaryotic cells of a Bordetella bronchiseptica mutant carrying an insertion in the locus encoding the response regulator RisAS is impaired. This suggested that ris-dependent products are required for the intracellular survival of bacteria. In this study we demonstrate that ris-regulated products play a role in B. bronchiseptica resistance against both phagosomal acidification and reactive oxygen intermediates.