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Related Experiment Video

Updated: Jul 3, 2026

Sequential Extraction of Soluble and Insoluble Alpha-Synuclein from Parkinsonian Brains

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Published on: January 5, 2016

Alpha-synuclein and the Lewy body disorders.

¹Department of Pathology, Mayo Clinic, Jacksonville, Florida 32224, USA. dickson.dennis@mayo.edu

Current Opinion in Neurology

|July 27, 2001

Summary

Alpha-synuclein protein aggregation is linked to synucleinopathies, a group of neurodegenerative diseases. Research is ongoing to understand if these protein inclusions are adaptive or cause cell degeneration.

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Technique for Intranasal Administration of α-Synuclein Aggregates

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Published on: November 8, 2024

Area of Science:

Neuroscience
Molecular Biology
Pathology

Background:

Alpha-synuclein (α-synuclein) is increasingly recognized for its role in neurodegenerative diseases called synucleinopathies.
Synucleinopathies present with diverse clinical symptoms, including parkinsonism, autonomic dysfunction, and dementia.

Purpose of the Study:

To summarize the current understanding of synucleinopathies, focusing on clinical, neuropathological, and biochemical aspects.
To explore the molecular mechanisms underlying alpha-synuclein aggregation in neurons and glia.

Main Methods:

Review of clinical, neuropathologic, and biochemical characterizations of synucleinopathies.
Analysis of molecular modifications of alpha-synuclein favoring fibrillization and aggregation.

Main Results:

Significant progress has been made in characterizing synucleinopathies and differentiating them from other neurodegenerative disorders.
Molecular insights reveal conformational and post-translational changes in alpha-synuclein that promote aggregation.

Conclusions:

Alpha-synuclein aggregation in neuronal and glial inclusions is a hallmark of synucleinopathies.
The precise role of inclusion body formation in disease pathogenesis remains an active area of investigation.