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[The study on relation of human papillomavirus and P53 expression with bladder transitional cell carcinoma]
Objective:
To study the relationship between the bladder transitional cell carcinoma and the human papillomavirus (HPV) types 6, 11, 16, 18 and P53.
Methods:
We used polymerase chain reaction (PCR) to test HPV type 6, 11, 16 and 18 infection from 75 cases of bladder cancer, and used immunohistochemistry method to detect P53 expression.
Results:
The positive rates of HPV types 6, 11, 16 and 18 were 6.7%, 5.3%, 33.3% and 6.7%, respectively. The positive rate of low risk HPV type (6/11) was 9.3% (7/75), and that of high risk HPV types (16/18) was 34.7% (26/75). There were 8 cases with two or three HPV types mixed infection, accounting for 10.6%, HPV types 6,11,16,18 in tumor metastasis group were significantly higher than that in non-metastasis group. The positive rates of HPV 16, 18 types in G3 were significantly higher than that in G1 and G2. HPV type 16 was the main type in bladder cancer. Positive rate of P53 expression was 44%.
Conclusions:
These results implicated that the occurrence and development of bladder transitional cell carcinoma may be closely related to the high risk HPV type infection and P53 expression.