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Potential risks and prevention, Part 2: Drug-induced permanent disabilities.

W N Kelly1

  • 1Department of Pharmacy Administration, Southern School of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341-4155, USA. kelly_wn@mercer.edu

American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
|July 27, 2001
PubMed
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Drug-induced permanent disabilities are a significant concern, with 84% deemed preventable. Pharmacists could have intervened in 40% of these preventable cases, highlighting the need for improved medication safety practices.

Area of Science:

  • Pharmacovigilance
  • Drug Safety
  • Medical Risk Management

Background:

  • Adverse drug events (ADEs) can lead to permanent disabilities.
  • Understanding risk factors and preventability is crucial for patient safety.

Purpose of the Study:

  • To investigate potential risk factors for drug-induced permanent disabilities.
  • To assess the preventability of these disabilities and identify contributing factors.

Main Methods:

  • Analysis of 227 case reports of drug-induced permanent disabilities from Clin-Alert (1978-1997).
  • Assessment of causality, predictability, and preventability for each case.
  • Categorization of patient, drug, and event variables.

Main Results:

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  • Antimicrobials, vaccines, CNS agents, and antineoplastics were common drug categories.
  • Medication errors (55%) and adverse drug reactions (43%) were primary event types.
  • 84% of disabilities were preventable, with 40% potentially preventable by pharmacists.

Conclusions:

  • Drug-induced permanent disabilities represent a preventable harm.
  • Interventions targeting medication errors and optimizing drug use can reduce incidence.
  • Pharmacist involvement is key in preventing a significant portion of these adverse outcomes.