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Bradykinin levels in dental pulp by microdialysis
A M Lepinski1, K M Hargreaves, H E Goodis
1University of Minnesota, School of Dentistry, Minneapolis, MN, USA.
Journal of Endodontics
|July 27, 2001
Summary
Extracellular bradykinin levels are significantly elevated in human dental pulp with irreversible pulpitis, indicating its role in dental pain and inflammation. This suggests the bradykinin system is activated during pulpitis.
Area of Science:
- Dentistry
- Pain Research
- Neuroscience
Background:
- Bradykinin is a key mediator of pain and inflammation.
- Understanding bradykinin's role in dental pulp is crucial for pain management.
Purpose of the Study:
- To measure extracellular bradykinin levels in human dental pulp.
- To investigate the association between bradykinin and irreversible pulpitis.
Main Methods:
- Microdialysis probes were used to collect samples from 22 human teeth.
- Samples were analyzed for bradykinin concentration using radioimmunoassay.
Main Results:
- Extracellular bradykinin levels were significantly higher in teeth with irreversible pulpitis (262.26 fmol/ml) compared to normal pulp (19.41 fmol/ml).
- Elevated bradykinin correlated with reported pain history in patients with irreversible pulpitis.
Conclusions:
- The bradykinin system is activated in irreversible pulpitis.
- Bradykinin likely contributes to the pain and inflammation associated with dental pulp conditions.
