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High-throughput Identification of Synergistic Drug Combinations by the Overlap2 Method
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Ribozyme pharmacokinetic screening for predicting pharmacodynamic dosing regimens

T J Parry1, K S Bouhana, K S Blanchard

  • 1Human Genome Sciences, Inc, Rockville, MD 20850, USA.

Current Issues in Molecular Biology
|July 27, 2001
PubMed
Summary

Pharmacokinetic analysis optimizes dosing for synthetic ribozymes like ANGIOZYME, which targets vascular endothelial growth factor receptor (Flt-1) mRNA. This approach is crucial for developing systemic therapies against metastatic cancer.

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