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A randomized comparison of triple therapy Helicobacter pylori eradication regimens in children with peptic ulcers

P L Shcherbakov1, V A Filin, I A Volkov

  • 1Russian State Medical University, Moscow.

The Journal of International Medical Research
|July 27, 2001
PubMed

Insights

Proprietary omeprazole combined with antibiotics showed higher Helicobacter pylori eradication rates in children with peptic ulcers compared to generic omeprazole or ranitidine. This triple therapy effectively treats H. pylori and aids ulcer healing.

Area of Science:

  • Pediatric Gastroenterology
  • Infectious Diseases
  • Pharmacology

Background:

  • Peptic ulcer disease in children often involves Helicobacter pylori infection.
  • Effective eradication of H. pylori is crucial for ulcer healing and preventing recurrence.
  • Optimizing treatment regimens for pediatric H. pylori infections is an ongoing clinical need.

Purpose of the Study:

  • To compare the efficacy of three different anti-secretory agents in combination with metronidazole and amoxycillin for H. pylori eradication in children.
  • To evaluate the impact of proprietary omeprazole, generic omeprazole, and ranitidine on H. pylori eradication rates and ulcer healing.
  • To determine the most effective triple therapy regimen for pediatric peptic ulcer disease associated with H. pylori.

Main Methods:

  • An open, randomized trial involving 106 children aged 5-15 years with peptic ulcer disease.
  • Treatment duration of 1 week with metronidazole, amoxycillin, and one of three anti-secretory agents: proprietary omeprazole, generic omeprazole, or ranitidine.
  • Assessment of H. pylori eradication rates and ulcer healing based on the prescribed regimen.

Main Results:

  • The H. pylori eradication rate was highest with proprietary omeprazole (88.9%), followed by generic omeprazole (80.0%), and ranitidine (74.3%).
  • A trend towards faster ulcer healing was observed in patients receiving proprietary omeprazole.
  • Triple therapy demonstrated effective H. pylori eradication and ulcer healing in the pediatric population.

Conclusions:

  • Triple therapy using an anti-secretory agent and two antimicrobials is effective for H. pylori eradication and ulcer healing in children.
  • Proprietary omeprazole demonstrated superior efficacy compared to ranitidine and the generic omeprazole formulation used in this study.
  • The findings support the use of proprietary omeprazole in combination regimens for treating pediatric H. pylori-associated peptic ulcer disease.

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