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Published on: November 22, 2015
Qualitative and quantitative analyses of resin-bound organic compounds
1ChemRx Advanced Technologies, 385 Oyster Point Boulevard, South San Francisco, CA 94080, USA.
Abstract:
Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.
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