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Updated: Oct 5, 2026

A New Straightforward Method for Lipophilicity (logP) Measurement using 19F NMR Spectroscopy
Published on: January 30, 2019
Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention
1Hit Generation Sciences and Analytical Technologies, GlaxoWellcome Medicines Research Centre, Stevenage, Herts, SG1 2NY, United Kingdom.
Abstract:
We propose a rapid method for the measurement of octanol/water partition coefficients (log P(oct)) via fast gradient reversed phase retention and the calculation of the hydrogen bond acidity of the compounds. The cycle time of the generic gradient HPLC method is 5 minutes. The general solvation equation obtained for the log Poct values and the fast gradient Chromatographic Hydrophobicity Indices with acetonitrile (CHI(ACN)) and methanol
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