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Related Experiment Videos

Peritoneal dialysis: new developments and new problems.

C W Gradden1, R Ahmad, G M Bell

  • 1Renal Unit, Royal Liverpool University Hospital Trust, Liverpool, UK. farndon@freeuk.com

Diabetic Medicine : a Journal of the British Diabetic Association
|July 27, 2001
PubMed
Summary
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Icodextrin-based peritoneal dialysis (PD) can lead to hyponatraemia (low sodium), particularly in diabetic patients. This risk factor may cause serious symptoms when combined with other health issues.

Area of Science:

  • Nephrology
  • Endocrinology
  • Internal Medicine

Background:

  • Hyponatraemia is a common complication in patients undergoing dialysis.
  • Icodextrin is a commonly used osmotic agent in peritoneal dialysis solutions.
  • The impact of icodextrin on sodium levels, especially in diabetic patients, requires further investigation.

Purpose of the Study:

  • To determine the incidence of hyponatraemia in patients on peritoneal dialysis (PD).
  • To assess the effect of icodextrin-based PD solutions on hyponatraemia in diabetic and non-diabetic individuals.

Main Methods:

  • Retrospective analysis of PD patient data, including plasma sodium, albumin, and renal function.
  • Comparison of patients using icodextrin-based solutions versus dextrose-based solutions.

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  • Statistical analysis using the paired Student's t-test.

    • Main Results:

    • Patients on icodextrin-based PD exhibited significantly lower plasma sodium levels compared to those on dextrose-based solutions.
    • Plasma sodium levels decreased in all patients after initiating icodextrin-based PD.
    • The decline in plasma sodium was statistically significant in both diabetic and non-diabetic patients, falling below reference ranges primarily in diabetic patients.

    Conclusions:

    • Icodextrin-based peritoneal dialysis is identified as a risk factor for developing hyponatraemia.
    • Clinically significant symptoms may arise if hyponatraemia is exacerbated by other patient-specific factors.