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Published on: September 9, 2014
[Serum transferrin receptor in healthy children]
M F Vázquez López1, A Carracedo Morales, J Muñoz Vico
1Servicios de Pediatría Hospital Torrecárdenas, Almería. mavazquezl@terra.es
Anales Espanoles De Pediatria
|July 27, 2001
Summary
Serum transferrin receptor (sTfR) levels are higher in children due to growth-related iron needs. These levels correlate with erythropoietic activity and iron status, providing a reference for healthy children.
Area of Science:
- Pediatric Hematology
- Iron Metabolism
- Biomarker Research
Context:
- Serum transferrin receptor (sTfR) is a known indicator of iron status and erythropoiesis in adults.
- Its role and reference ranges in healthy children remain less understood.
- Assessing iron status in children is crucial for monitoring growth and development.
Purpose:
- To establish reference ranges for sTfR concentrations in healthy children aged 1-10 years.
- To investigate age and sex-related variations in sTfR levels.
- To explore the relationship between sTfR, iron status parameters, and erythropoietin.
Summary:
- sTfR, sTfR/ferritin ratio, and sTfR-ferritin index were measured in 155 healthy children.
- Elevated sTfR levels were observed, particularly in younger children (1-2 years).
- sTfR correlated positively with erythrocyte count, hemoglobin, and total iron binding capacity, and was predicted by erythropoietin and total iron binding capacity.
Impact:
- Provides essential reference values for sTfR in healthy pediatric populations.
- Highlights the influence of growth on iron requirements and sTfR levels in children.
- Supports the use of sTfR as a biomarker for erythropoietic activity and iron status in pediatric research and clinical practice.
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