Electrophysiological signs of reduced prefrontal response control in schizophrenic patients

The prefrontal cortex is considered as a brain region important in the etiopathogenesis of schizophrenic disorders. Based on converging results from different research areas, the prefrontal cortex is regarded as the anatomical and functional representation of response control under physiological conditions. In previous studies, a robust electrophysiological marker for the investigation of response control in healthy control subjects was validated. This parameter was termed NoGo anteriorisation and consists of a more anterior peak of the event-related potentials during the inhibition of a prepared motor response (NoGo condition within the Continuous Performance Test) than during its execution (Go condition). The present study investigated these brain electrical correlates of response control in 19 schizophrenic patients and 19 age- and sex-matched healthy subjects. Compared to control subjects, the event-related potentials in schizophrenic patients were located more anterior in the Go condition and, as a trend, more posterior in the NoGo condition. The NoGo anteriorisation was strongly reduced in the schizophrenic group. On a qualitative level, the NoGo anteriorisation was present in all control subjects, but not in eight of the 19 patients. The results were interpreted as an indication of a disturbed prefrontal response control in schizophrenic patients. Further studies will clarify whether this method may be useful as a global test of hypofrontality in different groups of chronic schizophrenias, or as a quantifiable measure of an affected response control system, especially in catatonic subgroups.