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Peripheral arterial disease in diabetic and nondiabetic patients: a comparison of severity and outcome

E B Jude1, S O Oyibo, N Chalmers

  • 1Department of Medicine, Manchester Royal Infirmary, Manchester, UK. ejude@dc.cmht.nwest.nhs.uk

Diabetes Care
|July 27, 2001
PubMed

Insights

Diabetic patients with peripheral arterial disease (PAD) experience more severe arterial blockages and worse outcomes, including higher amputation and mortality rates, compared to nondiabetic individuals. This highlights PAD

Area of Science:

  • Vascular Surgery
  • Diabetology
  • Cardiology

Background:

  • Peripheral arterial disease (PAD) is a significant complication of diabetes.
  • Understanding the differential distribution and severity of PAD in diabetic versus nondiabetic populations is crucial for patient management.

Purpose of the Study:

  • To quantify the distribution and severity of peripheral arterial disease in diabetic and nondiabetic patients undergoing angiography.
  • To compare clinical outcomes, including revascularization, amputation, and mortality, between these two groups.

Main Methods:

  • Analysis of 136 lower-extremity angiograms using the Bollinger system.
  • Collection of patient demographics and medical history.
  • Review of case notes to determine subsequent revascularization, amputation, or death.

Main Results:

  • Diabetic patients exhibited greater arterial disease severity below the profunda femoris.
  • Diabetic patients had a significantly higher likelihood of amputation (OR 5.4) and mortality (OR 3.1).
  • Despite similar age and risk factors, a higher proportion of diabetic patients were hypertensive.

Conclusions:

  • Diabetic patients with PAD present with more severe disease and poorer outcomes than their nondiabetic counterparts.
  • Diabetes is associated with a substantially increased risk of amputation and mortality in PAD patients.
  • These findings underscore the need for aggressive management of PAD in diabetic individuals.
Abstract

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