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Related Experiment Videos

CD30 expression in follicular lymphoma.

L J Gardner1, J M Polski, H L Evans

  • 1Division of Hematopathology, Department of Pathology, St Louis University Health Sciences Center, St Louis, MO, USA.

Archives of Pathology & Laboratory Medicine
|July 28, 2001
PubMed
Summary
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CD30 expression is observed in a subset of follicular lymphomas (FL), indicating a broader spectrum of this disease. This finding highlights the importance of considering CD30 in FL diagnosis.

Area of Science:

  • Hematopathology
  • Immunohistochemistry
  • Lymphoma Research

Background:

  • CD30 is an activation marker found in various lymphomas, including anaplastic large cell lymphoma.
  • CD30 expression has been noted in diffuse large B-cell lymphoma and follicular lymphoma (FL).

Observation:

  • An index case of FL presented with CD30-positive cells exhibiting significant cellular pleomorphism.
  • Immunohistochemistry confirmed CD30 expression on pleomorphic cells within the malignant nodules of FL.

Findings:

  • 32% of additional FL cases showed definitive CD30-positive, large, pleomorphic malignant cells via paraffin immunohistochemistry.
  • In 9% of cases, CD30 staining patterns included clustering and variable staining of large cells.

Implications:

Related Experiment Videos

  • The morphologic and immunophenotypic spectrum of FL is broader than previously recognized.
  • CD30 staining should be considered in the diagnostic evaluation of follicular lymphoma.