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Simplified microneutralization test for serotyping adenovirus isolates
M D Malasig1, P R Goswami, L K Crawford-Miksza
1Department of Defense Center for Deployment Health Research, Naval Health Research Center, San Diego, California 92186, USA. malasig@nhrc.navy.mil
Journal of Clinical Microbiology
|July 28, 2001
Abstract:
A simplified microneutralization procedure is described that uses an empirically determined virus challenge dose, a single dilution of antiserum, and observation of cytopathic effect to determine the adenovirus serotype. The simplified test has faster turnaround time and was 96% concordant with a confirmatory test using serial dilutions of type-specific sera. This method will find utility in high-volume serotyping work.