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Related Experiment Videos

Amiodarone and radiation therapy sequelae.

C M Wilkinson1, G J Weidner, A C Paulino

  • 1Division of Radiation Oncology, University of Iowa College of Medicine, Iowa City, Iowa, USA.

American Journal of Clinical Oncology
|July 28, 2001
PubMed
Summary
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Amiodarone, an antiarrhythmic drug, can be safely used with external beam radiation therapy. This study found no treatment delays due to amiodarone-related side effects in patients receiving radiotherapy.

Area of Science:

  • Oncology
  • Cardiology
  • Radiotherapy

Background:

  • Amiodarone is an antiarrhythmic medication increasingly used in aging populations.
  • Anecdotal reports suggest potential mucosal and cutaneous toxicity when amiodarone is combined with external beam radiotherapy.
  • The concurrent use of amiodarone and radiotherapy necessitates a review of treatment outcomes and safety.

Purpose of the Study:

  • To evaluate the safety and feasibility of concurrent amiodarone use during external beam radiotherapy.
  • To determine if amiodarone administration leads to treatment delays or acute sequelae in radiotherapy patients.

Main Methods:

  • Retrospective review of 10 cases at the University of Iowa Hospitals and Clinics.
  • Analysis of patients receiving oral amiodarone concurrently with external beam radiation therapy over a 12-year period.

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Main Results:

  • No missed treatment fractions were observed in the 10 cases reviewed.
  • No unexpected acute sequelae directly attributable to the concurrent use of amiodarone and radiotherapy were reported.

Conclusions:

  • Concurrent amiodarone use does not contraindicate the delivery of therapeutic external beam radiotherapy.
  • Amiodarone can be safely administered to patients undergoing radiotherapy without compromising treatment schedules or causing significant acute toxicity.