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Updated: Jul 8, 2026

High Content Screening in Neurodegenerative Diseases

High Content Screening in Neurodegenerative Diseases

Published on: January 6, 2012

Admissions screening: clinical benefits.

C C Korvin, R H Pearce, J Stanley

Annals of Internal Medicine

|August 1, 1975

Summary

Routine laboratory screening in hospitals yields many abnormal results, but few lead to significant patient benefit. Careful evaluation is needed to determine the clinical value of these diagnostic findings.

Area of Science:

Clinical chemistry
Hematology
Diagnostic testing

Background:

Routine laboratory testing is common in hospitalized patients.
Assessing the clinical utility of numerous abnormal test results is crucial for efficient healthcare.

Purpose of the Study:

To evaluate the clinical benefit of routine chemical and hematologic tests in hospitalized patients.
To determine the diagnostic yield and impact of abnormal laboratory findings.

Main Methods:

Prospective analysis of 20 chemical and hematologic tests for 1000 patients admitted to a general hospital.
Assessment of potential clinical benefit for all abnormal results identified.

Main Results:

2223 abnormal results were found in 1000 patients.

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Only 83 new diagnoses were made in 77 patients, with no unequivocally beneficial outcomes.

Up to 30 patients may have benefited from diligent follow-up; 39 had insignificant findings.

Conclusions:

Despite a high number of abnormal screening tests, the clinical benefits are not impressive.
The diagnostic yield of routine laboratory screening requires critical evaluation to justify its use.
Further research into optimizing laboratory test selection and follow-up protocols is warranted.