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Related Experiment Videos

Microelectromechanical systems technology to deliver insulin.

D Liepmann1, A P Pisano, B Sage

  • 1Berkeley Sensor & Actuator Center, University of California at Berkeley, Berkeley, California, USA. liepmann@me.berkeley.edu

Diabetes Technology & Therapeutics
|July 28, 2001
PubMed
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Microelectromechanical systems (MEMS) enable precise, low-cost drug delivery. This technology is being developed for a compact, self-contained insulin delivery system, improving parenteral administration.

Area of Science:

  • Biomedical Engineering
  • Microfabrication Technology
  • Drug Delivery Systems

Background:

  • Microelectromechanical systems (MEMS) offer advanced capabilities for microscale fluid handling.
  • Current drug delivery systems require improvement in precision and miniaturization.
  • The Defense Advanced Research Projects Agency (DARPA) is funding novel drug delivery solutions.

Purpose of the Study:

  • To describe the microscale components for a novel drug delivery system utilizing MEMS technology.
  • To adapt MEMS technology for precise insulin reconstitution and delivery.
  • To develop a compact, self-contained parenteral drug delivery device.

Main Methods:

  • Utilizing MEMS fabrication methods, similar to microelectronics, for creating microscale components.

Related Experiment Videos

  • Developing MEMS-based components for precise control of fluid movement at the microscale.
  • Integrating these components into a drug delivery system for controlled reconstitution and delivery.

    • Main Results:

    • MEMS technology enables the precise movement and control of fluids at the microscale.
    • The developed system allows for the reconstitution and delivery of minute drug quantities with high accuracy.
    • The manufacturing method is intrinsically low-cost, making it suitable for widespread adoption.

    Conclusions:

    • MEMS technology is a viable and cost-effective solution for advanced drug delivery systems.
    • The developed system promises a fully self-contained parenteral drug delivery device, approximately credit card-sized.
    • This innovation has significant potential for improving insulin delivery and other parenteral therapies.