[Prostatic adenocarcinoma with neuroendocrine differentiation of the small cell type]

Adenocarcinomas (AC) account for more than 90% of the prostatic malignant neoplasias; a neuroendocrine differentiation (NE) component is to be considered in cases of atypical evolution for its diagnostic and therapeutic relevance. The (NE) originates by proliferation of the NE cells of the acinar epithelium and may develop into two different histologic patterns, a "Carcinoid" type and a "Small Cell" type. We report a patient with a prostatic AC diagnosed 5 years before his death with worsening of the disease together with a return of the prostatic specific antigen (PSA) to normal values and the presence of hepatic metastases of a tumor (NE) of the small cell type. The autopsy confirmed the presence of a prostatic tumor with areas of (AC) type and (NE) small cell type and multiple hepatic metastases (NE).