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[Behavioral disorders after treatment with isoniazid]
1Service de médecine interne, Hôpital national de Niamey et Faculté des sciences de la santé, B. P. 12278, Niamey, Niger.
Bulletin De La Societe De Pathologie Exotique (1990)
|July 28, 2001
Summary
Isoniazid, an effective tuberculosis drug, can cause neuropsychiatric side effects. Pyridoxine (vitamin B6) supplementation may prevent these isoniazid-induced adverse events.
Area of Science:
- Neuropsychiatry
- Pharmacology
- Infectious Diseases
Background:
- Isoniazid is a primary antituberculosis medication.
- Neuropsychiatric manifestations are potential adverse effects of isoniazid therapy.
- Mechanisms include pyridoxine deficiency and isoniazid toxicity, related to monoamine oxidase inhibition.
Observation:
- A 53-year-old male presented with psychotic symptoms potentially linked to isoniazid treatment.
- Predisposing factors such as slow acetylator status, diabetes, hepatic insufficiency, advanced age, alcoholism, and a history of mental illness were noted.
Findings:
- The patient's psychotic symptoms resolved favorably after discontinuing isoniazid.
- This case supports the hypothesis of isoniazid-induced psychosis.
Implications:
- Iatrogenic causes of neuropsychiatric symptoms during tuberculosis treatment should be considered.
- Systematic pyridoxine (vitamin B6) supplementation during isoniazid therapy is recommended to mitigate risks.