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Updated: Aug 10, 2026
06:55
Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
[Esophageal lesions associated with diphosphonates]
1Medisinsk avdeling Diakonhjemmets sykehus 0319 Oslo.
Summary
Bisphosphonates effectively prevent osteoporotic fractures but can cause esophageal issues. Early recognition of symptoms and proper medication instructions can minimize risks of severe esophageal damage.
Area of Science:
- Gastroenterology
- Pharmacology
- Orthopedics
Background:
- Bisphosphonates are crucial for inhibiting bone resorption and preventing osteoporotic fractures.
- However, bisphosphonates are associated with potential esophageal adverse events.
Observation:
- A series of seven patients presented with severe esophagitis or esophageal ulceration.
- These patients were undergoing bisphosphonate treatment during a 31-month observation period.
Findings:
- Six patients received alendronate, and one received etidronate.
- Discontinuation of bisphosphonates led to healing of esophageal lesions.
- Gastric acid suppression appeared to aid the healing process.
Implications:
- Detailed patient instructions on medication use are vital for minimizing bisphosphonate side effects.
- Early identification of esophageal symptoms and prompt intervention can reduce the risk of serious complications.
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