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Uric acid levels in patients with multiple sclerosis: analysis in mono- and dizygotic twins
S Spitsin1, D C Hooper, T Mikheeva
1Department of Immunology & Microbiology, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 28, 2001
Abstract:
Presence of nitrotyrosine in cells surrounding plaques indicates that peroxynitrite may be the cause of brain lesions in multiple sclerosis. Low levels of uric acid, a natural scavenger of peroxynitrite, were demonstrated in blood of patients with multiple sclerosis in comparison with control individuals. These observations were now extended to 132 sets of twins with one sibling affected by multiple sclerosis. In blood of both mono- and dizygotic twins the uric acid levels were lower in the twin with the disease than in the healthy twin.