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Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination--possible markers
1Department of Neuropathology, Charité, Humboldt-Universität, Berlin, Germany.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|July 28, 2001
Abstract:
The present report describes immunopathological, radiologcal and serological characteristics of antibody-mediated demyelination in a multiple sclerosis (MS) case with the main findings: (1) immunoglobulin and complement deposits in areas of active demyelination accompanied by massive macrophage activation; (2) ring-enhancing lesions in T1-weighted MRI after gadolinium application; (3) high titers of serum anti-myelin antibodies; and (4) signs of macrophage activation in the serum. Plasmapheresis may be a successful treatment for the type of inflammatory demyelination shown in the present case.