Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Immune restoration syndrome].

S Borrè1, R Brondolo, D Brustia

  • 1Struttura Complessa di Malattie Infettive, Azienda Ospedaliera Maggiore della Carità, Novara.

Recenti Progressi in Medicina
|July 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of gut barrier dysfunction during a viral respiratory disease challenge on immune function of feedlot beef calves.

Journal of animal science·2026
Same author

Host-parasite interactions of the sardine, Sardina pilchardus (Walbaum, 1792) from the Atlanto-Iberian Waters.

Parasitology research·2025
Same author

Morphological and genetic polymorphisms in Rhipicephalus sanguineus (Latreille 1806) from the Iberian Peninsula.

Parasitology research·2025
Same author

Epiglottic injury and airway management - a challenging and unexpected diagnosis.

Anaesthesia reports·2024
Same author

Correction to: Robotic‑assisted versus laparoscopic incisional hernia repair: a systematic review and meta‑analysis.

Hernia : the journal of hernias and abdominal wall surgery·2024
Same author

Impact of muscle mass loss on outcomes in advanced or metastatic gastric cancer patients receiving a second-line treatment.

European review for medical and pharmacological sciences·2024

A new syndrome, immune restoration syndrome (IRS), can occur in patients with certain infections when highly active antiretroviral therapy (HAART) begins. This rare condition is likely caused by an improved immune response to the infection.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Virology

Background:

  • Highly active antiretroviral therapy (HAART) has transformed HIV/AIDS management.
  • Opportunistic infections remain a challenge in patients with compromised immune systems.

Observation:

  • A novel syndrome, termed immune restoration syndrome (IRS), has been observed in patients with cytomegalovirus (CMV) retinitis, mycobacterial infections, or cryptococcosis.
  • This syndrome emerges following the initiation of HAART.

Findings:

  • The primary mechanism of IRS is hypothesized to be an enhanced immunologic reaction at the site of infection.
  • This reaction is attributed to improved T-lymphocyte function after HAART initiation.
  • The authors present a case of IRS in a patient diagnosed with atypical mycobacteriosis, highlighting its occurrence in specific mycobacterial infections.

Related Experiment Videos

Implications:

  • IRS represents a paradoxical immune response in immunocompromised patients undergoing treatment.
  • Understanding IRS is crucial for managing patients with opportunistic infections during HAART.
  • Further research is needed to elucidate the precise mechanisms and prevalence of IRS.