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Potential tuberculostatic agents: micelle-forming copolymer poly(ethylene glycol)-poly(aspartic acid) prodrug with
1Faculdade de Ciências Farmacêuticas, Universidade Estadual Paulista, CP502, 14801-902, Araraquara, SP, Brazil. hajudan@usp.br
Archiv Der Pharmazie
|July 31, 2001
Abstract:
With the objective of obtaining slow-acting isoniazid derivatives, of potential use as chemoprophylactics or chemotherapeutics in tuberculosis, the micelle-forming copolymer of poly(ethylene glycol)-poly(aspartic acid) prodrug with isoniazid was synthesized. The derivative obtained was found to be active in Mycobacterium tuberculosis culture, with a minimal inhibitory concentration (MIC) 5.6 times lower than that of the tuberculostatic drug.