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Anaphylaxis associated with antiphospholipid syndrome.

A Armentia¹, D Barber, M Lombardero

¹Allergy Section, Hospital Universitario Rio Hortega, Valladolid, Spain. jmartinsantos@nexo.es

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology

|July 31, 2001

Summary

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This study reveals a novel link between antiphospholipid syndrome and severe food-induced anaphylaxis. Four patients with antiphospholipid syndrome experienced anaphylaxis from specific food allergens, particularly a 45-kD almond protein.

Area of Science:

Immunology
Allergology
Rheumatology

Background:

The antiphospholipid syndrome (APS) is an autoimmune disorder associated with thrombosis and pregnancy complications.
Food-induced anaphylaxis is a severe allergic reaction to ingested foods.
No prior reports have linked food-induced anaphylaxis with APS.

Observation:

Four patients with APS experienced severe anaphylaxis after consuming specific vegetal foods.
These patients exhibited high levels of specific IgE antibodies to certain food allergens.
One patient developed a novel allergy to blackberry.

Findings:

All APS patients demonstrated specific IgE antibodies against food allergens.
Immunoblot analysis identified IgE specific to a 45-kD protein in almond extract in all four patients.

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No IgE antibodies targeting lipid transfer proteins were detected, suggesting other panallergens may be involved.

Implications:

This research highlights a previously unrecognized association between APS and severe food allergies.
It suggests potential novel food panallergens beyond lipid transfer proteins in APS patients.
Further investigation into this link could improve diagnosis and management of anaphylaxis in APS patients.