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Insulin release in cystic fibrosis
Archives of Disease in Childhood
|March 1, 1975
Summary
Children with cystic fibrosis show a reduced early insulin response to glucose, suggesting pancreatic fibrosis impacts insulin secretion and may contribute to diabetes risk. This finding was consistent across most patients studied.
Area of Science:
- Pediatrics
- Endocrinology
- Gastroenterology
Background:
- Cystic fibrosis (CF) is a genetic disorder primarily affecting the pancreas.
- Pancreatic dysfunction in CF can lead to malabsorption and potentially endocrine complications.
- The early insulin response to glucose in pediatric CF patients is not well-characterized.
Purpose of the Study:
- To investigate the early insulin secretory capacity in response to intravenous glucose challenge in children with cystic fibrosis.
- To correlate insulin response and glucose disappearance rate with clinical parameters in CF patients.
Main Methods:
- Seven pediatric patients (8 months to 9.5 years) with cystic fibrosis underwent rapid intravenous glucose injection.
- Plasma insulin levels were measured using radioimmunoassay.
- Blood glucose levels were determined, and the glucose disappearance rate (kG) was calculated.
Main Results:
- Most pediatric CF patients exhibited significantly lower early insulin response compared to normal controls.
- The glucose disappearance rate (kG) was normal in the studied CF cohort.
- Insulin response and kG did not correlate with disease duration or Shwachman score.
Conclusions:
- Progressive pancreatic fibrosis in cystic fibrosis likely impairs early insulin secretion.
- Reduced insulin response may predispose CF patients to the increased incidence of diabetes mellitus observed in the condition.
- Findings suggest a link between pancreatic exocrine and endocrine dysfunction in CF.
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