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Insulin release in cystic fibrosis

N I Kjellman, Y Larsson

    Archives of Disease in Childhood
    |March 1, 1975
    PubMed

    Insights

    Children with cystic fibrosis show a reduced early insulin response to glucose, suggesting pancreatic fibrosis impacts insulin secretion and may contribute to diabetes risk. This finding was consistent across most patients studied.

    Area of Science:

    • Pediatrics
    • Endocrinology
    • Gastroenterology

    Background:

    • Cystic fibrosis (CF) is a genetic disorder primarily affecting the pancreas.
    • Pancreatic dysfunction in CF can lead to malabsorption and potentially endocrine complications.
    • The early insulin response to glucose in pediatric CF patients is not well-characterized.

    Purpose of the Study:

    • To investigate the early insulin secretory capacity in response to intravenous glucose challenge in children with cystic fibrosis.
    • To correlate insulin response and glucose disappearance rate with clinical parameters in CF patients.

    Main Methods:

    • Seven pediatric patients (8 months to 9.5 years) with cystic fibrosis underwent rapid intravenous glucose injection.
    • Plasma insulin levels were measured using radioimmunoassay.
    • Blood glucose levels were determined, and the glucose disappearance rate (kG) was calculated.

    Main Results:

    • Most pediatric CF patients exhibited significantly lower early insulin response compared to normal controls.
    • The glucose disappearance rate (kG) was normal in the studied CF cohort.
    • Insulin response and kG did not correlate with disease duration or Shwachman score.

    Conclusions:

    • Progressive pancreatic fibrosis in cystic fibrosis likely impairs early insulin secretion.
    • Reduced insulin response may predispose CF patients to the increased incidence of diabetes mellitus observed in the condition.
    • Findings suggest a link between pancreatic exocrine and endocrine dysfunction in CF.

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