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Leucocyte function in children with kwashiorkor.

E U Rosen, J Geefhuysen, R Anderson

Archives of Disease in Childhood

|March 1, 1975

Summary

This summary is machine-generated.

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Children with kwashiorkor show depressed white blood cell counts but normal nitroblue tetrazolium reduction. Abnormal polymorphonuclear leucocyte function is linked to infection, not protein deficiency alone.

Area of Science:

Immunology
Pediatrics
Nutritional Science

Background:

Kwashiorkor, a severe form of malnutrition, can impact immune function.
Understanding the specific immune deficits in kwashiorkor is crucial for effective management.

Purpose of the Study:

To investigate the leukocyte response to infection in children with kwashiorkor.
To assess polymorphonuclear leucocyte chemotaxis, bactericidal activity, and nitroblue tetrazolium reduction.

Main Methods:

Comparative study of children with kwashiorkor and a control group.
Analysis of total leukocyte counts, lymphopenia, and nitroblue tetrazolium (NBT) reduction.
Evaluation of polymorphonuclear leucocyte chemotaxis and bactericidal activity.

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Main Results:

Children with kwashiorkor had depressed total leukocyte counts and frequent lymphopenia.
Nitroblue tetrazolium (NBT) reduction was found to be normal.
Abnormal polymorphonuclear leucocyte chemotaxis and bactericidal activity were observed but dependent on concurrent infection.

Conclusions:

Immune function in kwashiorkor appears largely normal, with some impairment in leukocyte mobilization during infection.
Protein depletion alone does not explain the observed abnormalities in polymorphonuclear leucocyte function.