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Masquerade syndrome: T-cell prolymphocytic leukemia presenting as panuveitis
S Dhar-Munshi1, P Alton, W H Ayliffe
1Croydon Eye Unit, Mayday University Hospital, Thornton Heath, Surrey, United Kingdom. sunil@webleicester.co.uk
Purpose:
To report a case of T-cell prolymphocytic leukemia with panuveitis as the primary presenting feature.
Methods:
Case report.
Results:
A 46-year-old woman presented with pain and blurred vision in the right eye. She was found to have signs of panuveitis with a central exudative retinal detachment. Further investigations revealed that she was suffering from the rare T-cell prolymphocytic leukemia. Both systemic and ocular manifestations of the disease resolved after chemotherapy with Campath-IH antigen and as she went into complete remission. The exudative detachment settled, and visual acuity recovered to 20/20.
Conclusion:
This case illustrates that leukemias can present with primarily ocular findings, and the sudden appearance of a serous retinal detachment with inflammatory signs in an otherwise healthy person warrants a thorough systemic screening for an underlying malignancy.