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Updated: Aug 7, 2026

Imaging G-protein Coupled Receptor (GPCR)-mediated Signaling Events that Control Chemotaxis of Dictyostelium Discoideum
Published on: September 20, 2011
GDNF recruits the signaling crew into lipid rafts
1Institute of Biotechnology, University of Helsinki, PO Box 56, Viikinkaari 9, FIN-00014, Helsinki, Finland. Mart.Saarma@helsinki.fi
Abstract:
Glial cell line-derived neurotrophic factor (GDNF) family ligands (GFL) are potent survival factors and regulators for central and peripheral neurons. GFLs bind to specific glycosyl phosphatidylinositol (GPI)-anchored co-receptors (GFRalpha1-alpha4), but signal through a common c-Ret receptor. Both GPI-anchored and soluble GFRalpha1 recruit c-Ret to lipid rafts following GDNF stimulation, where c-Ret interacts with different proteins than outside the rafts. Soluble GFRalpha1 mobilizes c-Ret to rafts by a different mechanism compared with GPI-anchored GFRalpha1.
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