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Related Experiment Videos

Diaphragmatic function in patients with chronic left ventricular failure.

M M. Carmo1, C Bárbara, T Ferreira

  • 1Departamento de Fisiopatologia da Faculdade de Ciências Médicas de Lisboa, Universidade Nova de Lisboa, Campo Santana, 130, 1198, Codex, Lisbon, Portugal

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|July 31, 2001
PubMed
Summary

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Respiratory muscle function in patients with moderate left ventricular failure (LVF) was evaluated. While diaphragm contribution to ventilation is preserved, its pressure-generating capacity is reduced, suggesting it’s an early affected muscle in LVF.

Area of Science:

  • Cardiology
  • Pulmonology
  • Physiology

Background:

  • Chronic moderate left ventricular failure (LVF) can impact respiratory muscle function, contributing to dyspnea and fatigue.
  • Understanding the specific role of respiratory muscles, particularly the diaphragm, is crucial for managing LVF symptoms.

Purpose of the Study:

  • To evaluate respiratory muscle function in patients with chronic moderate LVF (NYHA classes II-III).
  • To assess the contribution of respiratory muscles to the pathophysiology of dyspnea and fatigue in LVF.

Main Methods:

  • Studied 20 male patients with LVF and 19 age-matched controls.
  • Assessed volitional maneuvers (maximal inspiratory/expiratory pressures, sniff pressures) and non-volitional maneuvers (phrenic nerve magnetic stimulation for twitch pressures).

Related Experiment Videos

  • Measured pressures including oesophageal, gastric, and transdiaphragmatic.

    • Main Results:

    • No significant differences in maximal expiratory and inspiratory pressures between LVF patients and controls.
    • Sniff pressures were not significantly different between groups.
    • Oesophageal twitch pressure was significantly lower in LVF patients (11.4±3.4 cmH2O) compared to controls (16.3±6.8 cmH2O), P<0.004.

    Conclusions:

    • The diaphragm's contribution to total ventilation is preserved in moderate LVF.
    • However, the diaphragm's capacity to generate negative intrathoracic pressure is decreased, indicated by lower oesophageal twitch.
    • The diaphragm appears to be the initial inspiratory muscle affected in moderate LVF.