Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Peripheral or central densitometry: does it matter which technique we use?

G M Blake1, I Fogelman

  • 1Department of Nuclear Medicine, Guy's Hospital, St. Thomas Street, London SE1 9RT, United Kingdom. glen.blake@kcl.ac.uk

Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry
|July 31, 2001
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pancreas fat quantification with quantitative CT: an MRI correlation analysis.

Clinical radiology·2020
Same author

Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies.

The journal of prevention of Alzheimer's disease·2017
Same author

Correction to: 18F-NaF PET/CT: EANM procedure guidelines for bone imaging.

European journal of nuclear medicine and molecular imaging·2017
Same author

Changes in bone mineral density and bone turnover in patients on 'drug holiday' following bisphosphonate therapy: real-life clinic setting.

Clinical endocrinology·2015
Same author

Circulating concentrations of vitamin E isomers: Association with bone turnover and arterial stiffness in post-menopausal women.

Bone·2015
Same author

(18)F-NaF PET/CT: EANM procedure guidelines for bone imaging.

European journal of nuclear medicine and molecular imaging·2015
Same journal

Comparison of adenoma and gland hyperplasia on bone mineral density in primary hyperparathyroidism.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

The influence of pregnancy and selected aspects of female health on skeletal status and fracture incidence in postmenopausal women from the RACOST-POL Study.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

The association of sclerostin with osteoporosis and vertebral fractures in patients with type 2 diabetes mellitus.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

Assessment of bone microarchitecture in postmenopausal women with primary hyperparathyroidism using trabecular bone score.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

Erxian decoction for postmenopausal osteoporosis: An updated systematic review and meta-analysis.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
Same journal

Associations of discordance in hip bone mineral density with hip osteoarthrosis severity and progression to total hip replacement in middle-aged adults.

Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry·2026
See all related articles

Dual X-ray absorptiometry (DXA) is key for osteoporosis diagnosis. Peripheral bone density scans show promise, but interpretation guidelines are crucial for accurate fracture risk assessment and patient selection for treatment.

Area of Science:

  • Osteoporosis diagnosis and management
  • Medical imaging and diagnostics
  • Bone health and fracture risk assessment

Background:

  • Bone density scans, particularly dual X-ray absorptiometry (DXA), are vital for diagnosing osteoporosis.
  • Various peripheral bone density measurement devices are available, but lack of consensus on interpretation hinders their use.
  • Key questions arise regarding fracture risk identification, method agreement, and treatment selection based on different techniques.

Purpose of the Study:

  • To compare the effectiveness of different bone density measurement techniques in identifying patients at risk of fracture.
  • To explore scan interpretation approaches that ensure agreement among various measurement methods.
  • To evaluate the impact of different techniques on patient selection for osteoporosis treatment.

Related Experiment Videos

Main Methods:

  • Utilized relative risk (RR) derived from prospective studies to compare the clinical value of different bone density measurement techniques.
  • Employed receiver operating characteristic (ROC) curves to assess the impact of scan interpretation guidelines.
  • Compared hip bone mineral density with peripheral measurements for predicting hip fracture risk.

Main Results:

  • Hip bone mineral density demonstrated advantages over peripheral measurements in predicting hip fracture risk; differences for other fracture sites were inconclusive.
  • Scan interpretation guidelines significantly influence the effective use of bone density information.
  • Setting peripheral device thresholds to match the population or fracture case percentage of femur DXA achieved the closest agreement between techniques.

Conclusions:

  • Effective scan interpretation guidelines are crucial for accurate fracture risk assessment and patient management.
  • Peripheral bone density devices can be valuable when interpreted correctly, potentially being underestimated due to focus on correlation with DXA rather than fracture risk.
  • The technique yielding the highest relative risk (RR) value is the most successful in identifying individuals at future fracture risk.