Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Liver disease caused by propylthiouracil.

M S Fedotin, L G Lefer

    Archives of Internal Medicine
    |February 1, 1975
    PubMed
    Summary

    Propylthiouracil can cause chronic active hepatitis, a serious liver condition. This finding adds propylthiouracil to the list of drugs to consider when diagnosing chronic liver disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Modified phenol chemical face peels: recognizing the role of application technique.

    Facial plastic surgery clinics of North America·2001
    Same author

    Modified phenol chemical face peels: recognizing the role of application technique.

    Clinics in plastic surgery·2001
    Same author

    Helicobacter pylori and peptic ulcer disease. Reexamining the therapeutic approach.

    Postgraduate medicine·1993
    Same author

    Partial deployment of the Garren gastric bubble: a new complication.

    The American journal of gastroenterology·1987
    Same author

    Vesicles on the dorsa of the fingers. Porphyria cutanea tarda (PCT).

    Archives of dermatology·1987
    Same author

    Five-aminosalicylic acid enemas in treatment of ulcerative colitis.

    Missouri medicine·1985

    Area of Science:

    • Hepatology
    • Toxicology
    • Drug-induced Liver Injury

    Background:

    • Chronic liver disease evaluation requires identifying potential causative agents.
    • Drug-induced liver injury (DILI) is a significant concern in clinical practice.

    Purpose of the Study:

    • To report a case of chronic active hepatitis linked to propylthiouracil administration.
    • To highlight propylthiouracil as a potential cause of chronic liver disease.

    Main Methods:

    • Clinical case presentation.
    • Laboratory analysis.
    • Light and electron microscopy of liver tissue.

    Main Results:

    • The patient presented with chronic active hepatitis.
    • Histopathological findings confirmed aggressive hepatitis.
    • Causation was attributed to propylthiouracil treatment.

    Conclusions:

    • Propylthiouracil should be considered in the differential diagnosis of drug-induced chronic liver disease.
    • This case expands the spectrum of known adverse hepatic effects of propylthiouracil.

    Related Experiment Videos