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Related Experiment Videos

Coagulation markers predicting cardiac transplant rejection.

J B Segal1, E K Kasper, C Rohde

  • 1Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Transplantation
|July 31, 2001
PubMed
Summary

Plasma markers like p-selectin and prothrombin fragment 1.2 (PF1.2) can predict cardiac allograft rejection. These coagulation markers offer a potential noninvasive method for monitoring heart transplant recipients for rejection.

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Area of Science:

  • Cardiology
  • Transplantation Immunology
  • Coagulation Science

Background:

  • Acute cellular rejection is a primary cause of cardiac allograft loss.
  • Rejection is linked to the activation of the coagulation system.
  • Investigating coagulation markers for predicting rejection is crucial.

Purpose of the Study:

  • To determine if plasma coagulation markers predict cardiac allograft rejection.
  • To assess the relationship between specific markers and rejection severity.
  • To evaluate the potential for noninvasive monitoring of rejection.

Main Methods:

  • Collected 132 blood specimens and biopsies from 35 heart transplant patients.
  • Measured plasma levels of prothrombin fragment 1.2 (PF1.2), p-selectin, fibrinogen, thrombomodulin, and d-dimer.

Related Experiment Videos

  • Utilized linear and logistic regression analysis on biopsy-graded rejection.

    • Main Results:

    • p-Selectin levels increased with rejection severity (P<0.001).
    • Both p-selectin and PF1.2 levels significantly predicted rejection.
    • A model using p-selectin and PF1.2 predicted rejection with 85% accuracy.
    • High p-selectin levels (≥65 ng/ml) showed an odds of rejection of 21.4.

    Conclusions:

    • p-Selectin and PF1.2 levels are highly predictive of organ rejection in heart transplant recipients.
    • Elevated PF1.2 indicates systemic thrombin generation.
    • These markers may enable noninvasive monitoring for rejection and treatment response.