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Related Experiment Videos

Volumetric multishot echo-planar spectroscopic imaging.

J M Tyszka1, A N Mamelak

  • 1Division of Molecular Medicine, Beckman Research Institute of the City of Hope, Duarte, California 91010, USA. mtyszka@coh.org

Magnetic Resonance in Medicine
|July 31, 2001
PubMed
Summary
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This study introduces multishot echo-planar spectroscopic imaging (MEPSI) for rapid whole-brain metabolite mapping. This technique aids in diagnosing and treating brain diseases like cancer and epilepsy with improved efficiency.

Area of Science:

  • Neuroimaging
  • Magnetic Resonance Spectroscopy
  • Medical Physics

Background:

  • Focal cerebral diseases, including cancer and epilepsy, require accurate diagnostic tools.
  • Volumetric magnetic resonance spectroscopic imaging (MRSI) offers potential for disease diagnosis and treatment monitoring.
  • Existing MRSI techniques can be time-consuming, limiting clinical applicability.

Purpose of the Study:

  • To describe a novel strategy for volumetric multishot echo-planar spectroscopic imaging (MEPSI).
  • To enable rapid, whole-brain metabolite mapping for improved clinical diagnosis.
  • To develop a method applicable to various multishot MRSI trajectories.

Main Methods:

  • Implemented a multishot trajectory in both spatial and temporal domains for MEPSI.

Related Experiment Videos

  • Reduced accumulated phase during echo trains to enable conventional Fourier reconstruction.
  • Developed a generalized correction for phase discontinuities in multishot acquisitions.

    • Main Results:

    • Achieved whole-brain metabolite mapping in approximately 20 minutes.
    • Demonstrated high signal-to-noise ratios (SNRs) for key metabolites: n-acetylaspartate (NAA) (21.3 +/- 1.8), choline (Cho) (11.7 +/- 0.6), and creatine (Cr) (9.2 +/- 0.6).
    • Computed voxel size of 2.33 ml with lipid suppression.

    Conclusions:

    • MEPSI provides a rapid and effective method for whole-brain metabolite mapping.
    • The developed phase correction technique is versatile and applicable to other multishot MRSI methods.
    • This technique holds significant promise for the diagnosis and treatment of focal cerebral diseases.